Design and synthesis of novel inhibitors of gelatinase B.
نویسندگان
چکیده
A new method was developed to identify nonpeptidic metalloproteinase inhibitors with novel zinc binding groups. Application of this method to matrix metalloproteinase-9 resulted in the identification of aminomethyl benzimidazole analogue 7a with an IC(50)=13 microM.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 12 16 شماره
صفحات -
تاریخ انتشار 2002